Cellular Superstars: How NMN and Trans-resveratrol are Changing the Health Game

Resveratrol skincare products for youthful skin.

Welcome, health enthusiasts! 

Ever felt like you're on a never-ending quest to discover the golden elixirs of health and longevity? You're not alone. Mother Nature, in her endless wisdom, has gifted us a myriad of compounds that, once uncovered, seem to hold the secrets to vitality and youth. Today, we're putting the spotlight on two such wondrous compounds: NMN and Trans-Resveratrol. If these sound like terms from an advanced science class, worry not! We're about to embark on a fun-filled exploration.

As we age, our body's natural ability to repair and rejuvenate cells starts to wane. Environmental stress, poor dietary choices, and just the wear and tear of time can all leave our cells feeling a bit... tired. And tired cells can lead to early aging, reduced vitality, and a host of health issues. Enter our heroes, NMN and Trans-Resveratrol. By rejuvenating our cells, they offer the promise of more energetic days, radiant health, and potentially even a longer life.

As we delve deeper into this article, we’ll unpack the science behind these two, explore their myriad benefits, and even give you some top tips on how to incorporate them into your daily life. So, whether you're a seasoned health nut or just embarking on your wellness journey, there's something here for everyone.

Intrigued? Excited? Ready to take charge of your cellular health? Stay with me, and let’s dive deep into the fascinating world of NMN and Trans-Resveratrol!

NMN: The Marvel Molecule in Modern Medicine

Imagine your body's cells are like tiny, bustling cities. Now, every city needs energy to run smoothly, right? Enter NMN and its best friend, NAD+ – they're like the ultimate power duo providing that energy. NMN is basically the precursor to NAD+, which means it transforms into NAD+ inside our bodies. Think of it like a Pokémon evolution; NMN goes into our body, does a fancy little dance, and boom! It becomes NAD+.

Why is NAD+ so crucial, you ask? It's like the all-important battery that powers a lot of the essential processes in our cells, from repairing DNA damage to keeping our mitochondria (the cell's powerhouse) working efficiently. But, as we grow older, our natural NAD+ levels dip. And yeah, that's a bit of a bummer.

That's where NMN steps into the spotlight! By taking NMN, we might be able to boost those NAD+ levels back up, helping our cells stay vibrant and energetic. It's like giving those tiny city cells of ours a fresh supply of top-notch coffee to keep them awake and lively.

In short, NMN is our sneaky way of topping up the NAD+ tank in our cells, potentially helping us feel younger, energized, and ready to rock 'n roll! Now, let’s have a closer look at some fascinating studies regarding NMN!

Aging in Reverse? How NMN Breathed New Life into Mice

The gradual decrease of NAD+ as organisms age has been linked to various age-associated complications. In this groundbreaking study, Zhang and his team explored the rejuvenating potential of NAD+ replenishment in mice using NMN. The comprehensive research investigated various facets of aging, including mitochondrial and stem cell function. Remarkably, they observed that by restoring NAD+ concentrations through NMN supplementation, both mitochondrial and stem cell functions showed marked improvement. This, in turn, enhanced the overall lifespan of the treated mice, signifying the profound anti-aging benefits of NMN. The study paves the way for further research into human applications and the wider implications of NAD+ restoration.

Heart Hacks: NMN's Magic Touch on Aging Blood Vessels

Vascular health and its decline with aging is a key concern in the medical field. Das and colleagues delved into the intricacies of the endothelial NAD+-H2S signaling pathway. Their findings unveiled that this vital pathway undergoes dysfunction with age. However, there's hope. NMN supplementation showcased its potency by reversing these age-related deteriorations, effectively rejuvenating vascular health. These findings are especially crucial, suggesting that NMN could serve as a therapeutic intervention against vascular aging and related cardiovascular diseases.

Memory Lane: NMN's Fight Against Alzheimer's Culprits

Alzheimer's and other cognitive impairments are growing concerns worldwide. Wang's team conducted a pivotal study exploring the neuroprotective potential of NMN against β-amyloid oligomers, a known instigator of Alzheimer's. Their research not only demonstrated that NMN offered protection against these harmful oligomers but also mitigated cognitive decline and neuronal death. This significant discovery emphasizes NMN's potential in treating neurodegenerative diseases.

A profile of an older woman whose brain is depicted as a colorful forrest which represents flourishing effects of taking NMN to fight against Alzheimer

Metabolic Makeover: NMN's Answer to Aging & Weighty Issues

In a world grappling with obesity and metabolic disorders, Mills and associates highlighted the potential of NMN in regulating metabolic health. Their exhaustive study on mice revealed that prolonged NMN administration curtailed age-associated physiological decline. The results indicated better metabolic health and a potential safeguard against obesity, offering a promising avenue for combating metabolic disorders in the aging population.

DNA's New Bestie: NMN Shields and Repairs Genetic Gold

Li and his team embarked on a captivating exploration of NAD+'s influence on protein-protein interactions during aging. Their findings revealed a unique NAD+ binding pocket that plays a pivotal role in DNA repair and protection against radiation damage. With NMN's ability to boost NAD+ levels, the study underlines its potential in safeguarding genetic material and potentially protecting against radiation-induced damage.

Seeing Clearer with Age: NMN's Guard Against Glaucoma

Aging eyes and related disorders, such as glaucoma, can drastically impact quality of life. Williams and his colleagues ventured to understand if NMN, through its NAD+ boosting capabilities, could avert eye disorders. Their research on aged mice showcased that NMN supplementation not only fortified mitochondrial health but also successfully prevented glaucoma. This holds significant promise for therapeutic interventions in ocular health.

Muscle Mojo: NMN Flexes Against Aging Decline

Skeletal muscle deterioration is an inevitable consequence of aging. Frederick and his team highlighted the critical role of NAD+ homeostasis in maintaining muscle health. Their findings showed that loss of NAD+ led to muscle degeneration. However, this degeneration was reversible through NMN supplementation, illuminating its potential in muscle rejuvenation and overall physical health in aging individuals.

Liver Love: How NMN Turned the Tide on Fatty Liver Disease

Liver health is paramount for overall metabolic well-being. Gariani and colleagues dove deep into the potential of NMN in averting fatty liver disease. Their findings spotlighted that by boosting NAD+ using NMN, the mitochondrial unfolded protein response was elicited. This response effectively reversed fatty liver disease in mice, offering a beacon of hope for those with liver complications.

Immunity Boost 101: NMN's Secret Sauce for Age-Proof Defense

Age-associated decline in immunity is a pressing concern. Camacho-Pereira's team explored the CD38-mediated NAD+ decline and its effects on the immune system. Their study revealed that by regulating this pathway, NMN could play a pivotal role in bolstering the immune response, particularly in aged individuals. This paves the way for NMN's potential use in immunotherapy.

Skin's New BFF: NMN's Barrier Boost Against Aging & Sun's Sneaky Rays

Skin health, particularly during aging and after sun exposure, is a concern for many. Mendelsohn and Larrick embarked on an extensive study exploring the NAD+/PARP/SIRT1 axis in skin cells. Their findings shed light on the potential of NMN in fortifying skin barrier function and protecting against aging and photoaging damage. With NMN's NAD+-boosting properties, the study offers hope for innovative skincare therapies.

Next up, let’s focus our attention on Trans-Resveratrol!

A Grapeful Heart: Health Surprises with Trans-Resveratrol

Trans-resveratrol, a natural powerhouse derived predominantly from grapes, has firmly established its prominence in scientific circles and for good reason. This remarkable compound, the subject of a plethora of research studies, has showcased its multifaceted benefits for human health.

Studies have illuminated its potential in promoting cardiovascular wellness, safeguarding the brain's intricate structures, and even extending the tenacity of our bones. Beyond this, its role as a sentinel against cancer, a guardian for liver health, and a boost for physical performance paints a picture of a molecule that's nothing short of miraculous. And if that weren't enough, its influence on skin health positions it as a potential elixir for youthful vitality. When you delve into the world of trans-resveratrol, you're exploring nature's gift to holistic health and well-being.

Nature’s Chill Pill: Resveratrol's Answer to Inflammation

Csaki and colleagues wanted to know if resveratrol could be that cool, calming friend our bodies sometimes need. Inflammation Is a major buzzkill, right? It’s like the body's alarm going off at 3 am. So, the team tested if resveratrol could hit the snooze button. Good news: it kinda does! Especially for our joints, resveratrol seems to bring the chill vibes, reducing inflammation and telling those rowdy inflammatory signals to take a break. If our joints could talk, they’d probably be sending thank-you cards to resveratrol.

Red Wine Revelations: How Resveratrol Tunes Your Heart to the Beat

Ever heard the saying, "A glass of red wine a day keeps the doctor away?"

Found mostly in grapes, this marvelous molecule is pretty much a gym trainer for your heart. It boosts nitric oxide, which is like giving your heart’s blood flow a smooth expressway. On top of that, it stops platelets from sticking together - think of it like avoiding traffic jams in your blood vessels. And if that's not enough, it keeps an eye on the "bad cholesterol" like a strict teacher.

All these findings suggest that if our heart had a wishlist, resveratrol would definitely be at the top. Cheers to more red wine (in moderation, of course)!

A glass of red wine in front of a bottle with a red heart on it

Beyond the Fountain of Youth: Resveratrol's Age-Defying Magic

You know that dream where you've discovered the fountain of youth? Howitz and colleagues made it a reality – at least in the lab. They looked at how resveratrol can push back against time, and it’s like they found a small piece of the anti-aging puzzle. Working with yeast, they discovered that this magic compound could extend their lifespan! The way it activates certain proteins, sirtuins, feels like it's telling our cells to keep calm and carry on. The big takeaway? Resveratrol might be our ally in aging like fine wine. Who doesn't want that?

Brain-Boosting Grapes: Resveratrol’s Crusade Against Cognitive Decline

Kim and associates went on a brainy expedition. They were curious to see if resveratrol could be the brain's bodyguard, especially against baddies like Alzheimer's. And boy, did they strike gold! They found that it might help protect nerve cells and could play a role in battling neurodegeneration.

So, while we're solving crosswords to keep our minds sharp, resveratrol might be an inside agent, helping keep our gray matter in tip-top shape.

Grapes vs. Cancer: Resveratrol's Feisty Face-Off with the Big C

Jang's crew went full detective mode on resveratrol to see if it's got any anti-cancer mojo. And the results? Pretty darn promising. The team realized that this grape-lovin' molecule actually had some beef with cancer cells. Resveratrol seems to play the role of a bouncer, blocking the pathways that cancer cells might use to crash the party inside our body. What's cooler is how it seems to work against a variety of cancers. So, while it's no magic bullet, it sure looks like a handy sidekick in the fight against the big C.

Sugar’s New Supervisor: Resveratrol’s Stance Against Diabetes

Lagouge and team tackled the sugar monster – diabetes. They were curious: can resveratrol be the guardian angel for our blood sugar? Drumroll... yes! The molecule helps our body use sugar better and boosts mitochondrial function, making our cells more energy-efficient. It’s like resveratrol gives our cells a personal trainer to shape up and handle sugar like a pro. So, in the battle against the blood sugar blues, resveratrol might be that secret weapon we've been hoping for.

Bones & Berries: Resveratrol’s Blueprint for a Sturdier Skeleton

Bones are the unsung heroes of our bodies, and Ornstrup's squad decided to give them some love. Can resveratrol be the milk to our bones? Turns out, this molecule might be adding some sturdiness to our skeletal frame. The crew found that resveratrol can increase bone mineral density and, in simple terms, make them tougher. So, for all of us who want to dance to the beat even in our golden years, resveratrol might just be the backstage crew, setting the stage right.

Liver’s Loyal Guardian: Resveratrol’s Protective Embrace

Bujanda and the team took a liver-loving journey to see if resveratrol might be the ultimate detox for our hard-working liver. Let’s face it: our liver's the unsung hero processing all the junk we sometimes throw its way. What the crew found was super promising. Resveratrol seems to shield the liver from damage, especially when it's under attack from things like alcohol. It's like a gentle reminder to our liver saying, "Hey, I've got your back!" So next time you're thinking of that detox juice cleanse, maybe give a nod to resveratrol too.

Run, Lift, Dance: Resveratrol’s Energizing Overture

Dolinsky and associates went all sporty and dived into the exciting world of exercise. Can resveratrol be the ultimate pre-workout supplement? Their findings are like those moments when your workout playlist hits the perfect track. Resveratrol can ramp up stamina, helping muscles use oxygen more efficiently. In essence, it's like giving your muscles a pep talk, allowing you to potentially run longer, lift more, or just feel less pooped after a workout. So, the next time you're hitting the gym or just dancing around in your living room, remember, resveratrol might just be the hype-man your muscles need.

Sipping Towards Youthful Skin: Resveratrol's Radiance Remedy

Ndiaye and colleagues decided to dive into the beauty world, asking the golden question: can resveratrol be the secret to ageless skin? If your skincare routine is missing something, this might be it!

This wonder molecule is like a protective cloak against harmful UV rays, slowing down skin aging. Plus, it also boosts the production of collagen. Think of it like an invisible shield and a mini-factory working to keep your skin plump and fresh. Resveratrol could be the unsung hero in the quest for that forever-young glow.

Resveratrol skincare products for youthful skin.

Closing the Chapter But Opening New Doors

In the labyrinthine realms of cellular biochemistry, NMN and Trans-Resveratrol whisper tales of rejuvenation and vitality. They stand at the crossroads of hope and science, suggesting possibilities that were once the province of myths and legends. From the timeless quest for longevity to the modern fight against age-related maladies, they have emerged as potential guardians against time's relentless march. It's not just about adding years to life, but life to years, as research paints a picture of their potential in revitalizing mitochondria, the cell's powerhouse.

But these molecules don't stop at cellular invigoration; they extend their benevolent touch to our vascular highways, offering a fresher lease to an aging heart. And in the quiet chambers of our mind, they stand guard against lurking shadows like Alzheimer's. In a world grappling with metabolic challenges, they hint at metabolic equilibrium, while our muscles, those pillars of strength, might just find a new dawn of rejuvenation. They even beckon with promises of liver detoxification, sharper vision in twilight years, a fortified defense system, and radiant, resilient skin.

Each study, a testament to its potential, weaves a narrative of two substances that might just reshape our understanding of aging. As we stand on the cusp of a revolution in age-related therapies, NMN and Trans-Resveratrol gleam brightly, inviting us to envision a future where age is just a number and vibrant health is everyone's legacy.

Order our Vitruline Longevity Bundle today and start experiencing the benefits of Resveratrol and NMN for yourself. With our comprehensive approach to healthy aging, you'll look and feel your best in no time.


Zhang H, Ryu D, Wu Y, Gariani K, Wang X, Luan P, D'Amico D, Ropelle ER, Lutolf MP, Aebersold R, Schoonjans K, Menzies KJ, Auwerx J. NAD⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice. Science. 2016 Jun 17;352(6292):1436-43. doi: 10.1126/science.aaf2693. Epub 2016 Apr 28. PMID: 27127236.

Das A, Huang GX, Bonkowski MS, Longchamp A, Li C, Schultz MB, Kim LJ, Osborne B, Joshi S, Lu Y, Treviño-Villarreal JH, Kang MJ, Hung TT, Lee B, Williams EO, Igarashi M, Mitchell JR, Wu LE, Turner N, Arany Z, Guarente L, Sinclair DA. Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging. Cell. 2018 Mar 22;173(1):74-89.e20. doi: 10.1016/j.cell.2018.02.008. Erratum in: Cell. 2019 Feb 7;176(4):944-945. PMID: 29570999; PMCID: PMC5884172.

Wang X, Hu X, Yang Y, Takata T, Sakurai T. Nicotinamide mononucleotide protects against β-amyloid oligomer-induced cognitive impairment and neuronal death. Brain Res. 2016 Jul 15;1643:1-9. doi: 10.1016/j.brainres.2016.04.060. Epub 2016 Apr 26. PMID: 27130898.

Mills KF, Yoshida S, Stein LR, Grozio A, Kubota S, Sasaki Y, Redpath P, Migaud ME, Apte RS, Uchida K, Yoshino J, Imai SI. Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice. Cell Metab. 2016 Dec 13;24(6):795-806. doi: 10.1016/j.cmet.2016.09.013. Epub 2016 Oct 27. PMID: 28068222; PMCID: PMC5668137.

Li J, Bonkowski MS, Moniot S, Zhang D, Hubbard BP, Ling AJ, Rajman LA, Qin B, Lou Z, Gorbunova V, Aravind L, Steegborn C, Sinclair DA. A conserved NAD+ binding pocket that regulates protein-protein interactions during aging. Science. 2017 Mar 24;355(6331):1312-1317. doi: 10.1126/science.aad8242. PMID: 28336669; PMCID: PMC5456119.

Williams PA, Harder JM, Foxworth NE, Cochran KE, Philip VM, Porciatti V, Smithies O, John SW. Vitamin B3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice. Science. 2017 Feb 17;355(6326):756-760. doi: 10.1126/science.aal0092. PMID: 28209901; PMCID: PMC5408298.

Frederick DW, Loro E, Liu L, Davila A Jr, Chellappa K, Silverman IM, Quinn WJ 3rd, Gosai SJ, Tichy ED, Davis JG, Mourkioti F, Gregory BD, Dellinger RW, Redpath P, Migaud ME, Nakamaru-Ogiso E, Rabinowitz JD, Khurana TS, Baur JA. Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle. Cell Metab. 2016 Aug 9;24(2):269-82. doi: 10.1016/j.cmet.2016.07.005. PMID: 27508874; PMCID: PMC4985182.

Gariani K, Menzies KJ, Ryu D, Wegner CJ, Wang X, Ropelle ER, Moullan N, Zhang H, Perino A, Lemos V, Kim B, Park YK, Piersigilli A, Pham TX, Yang Y, Ku CS, Koo SI, Fomitchova A, Cantó C, Schoonjans K, Sauve AA, Lee JY, Auwerx J. Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice. Hepatology. 2016 Apr;63(4):1190-204. doi: 10.1002/hep.28245. Epub 2015 Dec 16. PMID: 26404765; PMCID: PMC4805450.

Camacho-Pereira J, Tarragó MG, Chini CCS, Nin V, Escande C, Warner GM, Puranik AS, Schoon RA, Reid JM, Galina A, Chini EN. CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism. Cell Metab. 2016 Jun 14;23(6):1127-1139. doi: 10.1016/j.cmet.2016.05.006. PMID: 27304511; PMCID: PMC4911708.

Mendelsohn AR, Larrick JW. The NAD+/PARP1/SIRT1 Axis in Aging. Rejuvenation Res. 2017 Jun;20(3):244-247. doi: 10.1089/rej.2017.1980. PMID: 28537485.

Baur JA, Sinclair DA. Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov. 2006 Jun;5(6):493-506. doi: 10.1038/nrd2060. Epub 2006 May 26. PMID: 16732220.

Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, Wood JG, Zipkin RE, Chung P, Kisielewski A, Zhang LL, Scherer B, Sinclair DA. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature. 2003 Sep 11;425(6954):191-6. doi: 10.1038/nature01960. Epub 2003 Aug 24. PMID: 12939617.

Kim, D., Nguyen, M. D., Dobbin, M. M., Fischer, A., Sananbenesi, F., Rodgers, J. T., ... & Tsai, L. H. (2007). The EMBO Journal, 26(13), 3169-3179.

Jang M, Cai L, Udeani GO, Slowing KV, Thomas CF, Beecher CW, Fong HH, Farnsworth NR, Kinghorn AD, Mehta RG, Moon RC, Pezzuto JM. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science. 1997 Jan 10;275(5297):218-20. doi: 10.1126/science.275.5297.218. PMID: 8985016.

Csaki C, Keshishzadeh N, Fischer K, Shakibaei M. Regulation of inflammation signalling by resveratrol in human chondrocytes in vitro. Biochemical Pharmacology. 2008 Feb;75(3):677-687. DOI: 10.1016/j.bcp.2007.09.014. PMID: 17959154.

Lagouge M, Argmann C, Gerhart-Hines Z, Meziane H, Lerin C, Daussin F, Messadeq N, Milne J, Lambert P, Elliott P, Geny B, Laakso M, Puigserver P, Auwerx J. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell. 2006 Dec 15;127(6):1109-22. doi: 10.1016/j.cell.2006.11.013. Epub 2006 Nov 16. PMID: 17112576. 

Ornstrup, M. J., Harsløf, T., Kjær, T. N., Langdahl, B. L., & Pedersen, S. B. (2014). Journal of Clinical Endocrinology & Metabolism, 99(12), 4720-4729.

Bujanda L, Hijona E, Larzabal M, Beraza M, Aldazabal P, García-Urkia N, Sarasqueta C, Cosme A, Irastorza B, González A, Arenas JI Jr. Resveratrol inhibits nonalcoholic fatty liver disease in rats. BMC Gastroenterol. 2008 Sep 9;8:40. doi: 10.1186/1471-230X-8-40. PMID: 18782455; PMCID: PMC2547101.

Dolinsky VW, Jones KE, Sidhu RS, Haykowsky M, Czubryt MP, Gordon T, Dyck JR. Improvements in skeletal muscle strength and cardiac function induced by resveratrol during exercise training contribute to enhanced exercise performance in rats. J Physiol. 2012 Jun 1;590(11):2783-99. doi: 10.1113/jphysiol.2012.230490. Epub 2012 Apr 2. PMID: 22473781; PMCID: PMC3424731.

Ndiaye, M., Philippe, C., Mukhtar, H., & Ahmad, N. (2011). Archives of Biochemistry and Biophysics, 508(2), 164-170.